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J Antimicrob Chemother. 2001 Jan;47(1):77-81.

In vitro activity of linezolid against multiply resistant Gram-positive clinical isolates.

Author information

1
Servicio de Microbiología, Hospital General Universitario 'Gregorio Marañón', Dr Esquerdo 46, 28007 Madrid, Spain. fgarrote@efd.net

Abstract

The in vitro activity of the oxazolidinone linezolid was compared with the activities of vancomycin and teicoplanin against 450 Gram-positive clinical isolates, including a variety of multiply resistant strains. Linezolid inhibited all microorganisms tested at < or = 4 mg/L, including methicillin- and teicoplanin-resistant staphylococci, glycopeptide-resistant enterococci, penicillin- and multiply resistant pneumococci and viridans streptococci, and erythromycin-resistant beta-haemolytic streptococci. The MIC(90) of linezolid for all isolates was 2 mg/L.

PMID:
11152434
DOI:
10.1093/jac/47.1.77
[Indexed for MEDLINE]

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