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Arch Soc Esp Oftalmol. 2000;75(5):333-8.

[Antiinflammatory capacity of topical ketorolac in experimental model of ocular inflammation].

[Article in Spanish]

Author information

1
Servicio de Oftalmología, Hospital Miguel Servet, Po. Isabel la Católica, 1-3, 50009 Zaragoza, Spain.

Abstract

PURPOSE:

We studied the antiinflammatory effect of topical Ketorolac-Tromethamine on a model of endotoxin-induced uveitis in albino rabbits.

METHODS:

Endotoxin-induced uveitis was produced by intravitreal injection in the right eye of 10 ng lipopolysaccharide (LPS) A Salmonella typhimurium endotoxin in 5 microl saline solution. We have used 60 animals (5 groups of 12 animals each). Control group (G-I) was injected with saline (5 microl); endotoxin group (G-II) was injected with 10 ng of endotoxin; groups III, IV and V were injected with the same amount of endotoxin and treated with topical ketorolac-tromethamine every 6, 4 and 2 hours respectively. The animals were sacrificed 24 hours after endotoxin administration. We determined the ocular clinical signs and inflammatory cells and protein concentration in the aqueous humor.

RESULTS:

In all the groups treated with Ketorolac-Tromethamine we observed a significant reduction (p<0.05) in all parameters studied when compared with those of the endotoxin group (G-II).

CONCLUSION:

Topical Ketorolac-Tromethamine has demonstrated a significant reduction of endotoxin-induced-uveitis inflammation.

PMID:
11151171
[Indexed for MEDLINE]

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