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J Allergy Clin Immunol. 2001 Jan;107(1):135-42.

Platelet-derived growth factor is involved in the augmentation of airway responsiveness through remodeling of airways in diesel exhaust particulate-treated mice.

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1
Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.

Abstract

BACKGROUND:

Thickening of the region adjacent to the basement membrane is a key component of the remodeling of the asthmatic airway and is caused by collagen deposition in the region.

OBJECTIVE:

We sought to clarify the role of platelet-derived growth factor (PDGF), a competence factor of fibroblast, in the enhanced airway responsiveness and remodeling in a murine model.

METHODS:

Diesel exhaust particulates (DEPs) were administered intranasally every other day for 2 weeks with or without anti-PDGF-beta neutralizing antibody or goat IgG. Pulmonary function was then analyzed by using whole-body plethysmography before and after acetylcholine inhalation.

RESULTS:

Anti-PDGF-beta neutralizing antibody significantly inhibited both the elevation of airway resistance elicited by 1.25 and 2.5 mg/mL acetylcholine and the increase in the airway wall thickening induced by DEPs. In addition, bronchoalveolar lavage fluid cell analysis revealed that anti-PDGF-beta neutralizing antibody did not affect cellular infiltration at the airways.

CONCLUSION:

PDGF plays an important role in the process of remodeling brought about by DEP exposure in mice.

PMID:
11150003
DOI:
10.1067/mai.2001.111433
[Indexed for MEDLINE]
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