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Curr Opin Neurol. 2000 Dec;13(6):715-20.

deltaFosB: a molecular switch underlying long-term neural plasticity.

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Department of Anesthesiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.


Numerous chronic perturbations have been shown to induce highly stable isoforms of the transcription factor deltaFosB in the brain in a region-specific manner. This review examines the functional consequences of the induction of deltaFosB in particular neuronal populations as well as its possible role in behavioral abnormalities such as drug addiction and movement disorders.

[Indexed for MEDLINE]

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