Surfactant and surfactant inhibitors in meconium aspiration syndrome

J Pediatr. 2001 Jan;138(1):113-5. doi: 10.1067/mpd.2001.109602.

Abstract

Surfactant indices and inhibitors were measured in lung lavage fluid from 8 infants with meconium aspiration syndrome (MAS) who were receiving mechanical ventilation and 11 healthy control subjects. Surfactant phospholipid and surfactant protein A content in MAS was not different from that of control subjects, but concentrations of total protein, albumin, and membrane-derived phospholipid were elevated. All infants with MAS had hemorrhagic pulmonary edema. These findings reinforce the notion of MAS as a toxic pneumonitis with epithelial disruption and proteinaceous exudation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Albumins / analysis
  • Blood Gas Analysis
  • Blood Urea Nitrogen
  • Bronchoalveolar Lavage Fluid / chemistry*
  • Case-Control Studies
  • Gestational Age
  • Hemorrhage / etiology
  • Humans
  • Infant, Newborn
  • Meconium Aspiration Syndrome / blood
  • Meconium Aspiration Syndrome / etiology
  • Meconium Aspiration Syndrome / pathology*
  • Meconium Aspiration Syndrome / therapy
  • Phospholipids / analysis
  • Plasma Volume
  • Proteins / analysis
  • Proteolipids / analysis
  • Pulmonary Edema / etiology
  • Pulmonary Surfactant-Associated Proteins
  • Pulmonary Surfactants / analysis*
  • Pulmonary Surfactants / antagonists & inhibitors*
  • Respiration, Artificial / methods
  • Time Factors

Substances

  • Albumins
  • Phospholipids
  • Proteins
  • Proteolipids
  • Pulmonary Surfactant-Associated Proteins
  • Pulmonary Surfactants