Abstract
Surfactant indices and inhibitors were measured in lung lavage fluid from 8 infants with meconium aspiration syndrome (MAS) who were receiving mechanical ventilation and 11 healthy control subjects. Surfactant phospholipid and surfactant protein A content in MAS was not different from that of control subjects, but concentrations of total protein, albumin, and membrane-derived phospholipid were elevated. All infants with MAS had hemorrhagic pulmonary edema. These findings reinforce the notion of MAS as a toxic pneumonitis with epithelial disruption and proteinaceous exudation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Albumins / analysis
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Blood Gas Analysis
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Blood Urea Nitrogen
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Bronchoalveolar Lavage Fluid / chemistry*
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Case-Control Studies
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Gestational Age
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Hemorrhage / etiology
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Humans
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Infant, Newborn
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Meconium Aspiration Syndrome / blood
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Meconium Aspiration Syndrome / etiology
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Meconium Aspiration Syndrome / pathology*
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Meconium Aspiration Syndrome / therapy
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Phospholipids / analysis
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Plasma Volume
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Proteins / analysis
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Proteolipids / analysis
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Pulmonary Edema / etiology
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Pulmonary Surfactant-Associated Proteins
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Pulmonary Surfactants / analysis*
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Pulmonary Surfactants / antagonists & inhibitors*
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Respiration, Artificial / methods
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Time Factors
Substances
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Albumins
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Phospholipids
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Proteins
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Proteolipids
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Pulmonary Surfactant-Associated Proteins
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Pulmonary Surfactants