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Aliment Pharmacol Ther. 2001 Feb;15(2):203-6.

Usefulness of Helicobacter pylori stool antigen test to monitor response to eradication treatment in children.

Author information

1
Paediatric clinic, University of Piemonte Orientale, Novara, Italy. oderda@med.unipmn.it

Abstract

BACKGROUND:

The monitoring of the results of eradication treatment is a crucial step for patients with Helicobacter pylori gastritis. A non-invasive test for H. pylori antigens in stools (HpSA) was recently validated for children.

AIM:

To evaluate the accuracy of HpSA in monitoring eradication treatment in children.

METHODS:

In 60 children, H. pylori gastritis was diagnosed by endoscopy and the 13C-urea breath test. The children were treated and returned for a follow-up (13)C-urea breath test 6 weeks after the end of treatment. Children were considered cured when the (13)C-urea breath test was negative. Stool were collected at baseline, and at 2 and 6 weeks. Stool antigens were measured by HpSA.

RESULTS:

According to (13)C-urea breath test, 6 weeks after the end of treatment 49 children were cured and 11 were still H. pylori-positive. The sensitivity and specificity of HpSA on stools collected 2 weeks after therapy were 100%. At 6 weeks specificity was 93.9 and sensitivity 100%. Results by visual reading were concordant with the plate-reader in all but two cases at baseline.

CONCLUSIONS:

HpSA is accurate for monitoring treatment in children as early as 2 weeks after therapy, when information is most useful and unachievable with other tests. Results by visual reading are accurate, and this can make the test cheaper and more practical.

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