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Nat Cell Biol. 2000 Dec;2(12):E231-6.

Paxillin and focal adhesion signalling.

Author information

1
Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA. turnerc@mail.upstate.edu

Abstract

To facilitate a rapid response to environmental change, cells use scaffolding - or adaptor - proteins to recruit key components of their signal-transduction machinery to specific subcellular locations. Paxillin is a multi-domain adaptor found at the interface between the plasma membrane and the actin cytoskeleton. Here it provides a platform for the integration and processing of adhesion- and growth factor-related signals.

PMID:
11146675
DOI:
10.1038/35046659
[Indexed for MEDLINE]

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