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Nat Cell Biol. 2000 Dec;2(12):915-21.

A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif.

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1
Pathology Department, Rambam Medical Center, Haifa, Israel.

Abstract

Here we describe a protein product of the human septin H5/PNUTL2/CDCrel2b gene, which we call ARTS (for apoptosis-related protein in the TGF-beta signalling pathway). ARTS is expressed in many cells and acts to enhance cell death induced by TGF-beta or, to a lesser extent, by other apoptotic agents. Unlike related septin gene products, ARTS is localized to mitochondria and translocates to the nucleus when apoptosis occurs. Mutation of the P-loop of ARTS abrogates its competence to activate caspase 3 and to induce apoptosis. Taken together, these observations expand the functional attributes of septins previously described as having roles in cytokinesis and cellular morphogenesis.

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PMID:
11146656
DOI:
10.1038/35046566
[Indexed for MEDLINE]

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