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Brain Res. 2001 Jan 5;888(1):163-166.

The anxiolytic effects of intra-hippocampal midazolam are antagonized by intra-septal L-glutamate.

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Douglas Hospital Research Center, 6875 LaSalle Boulevard, H4H 1R3, Montreal, PQ, Canada.


According to Gray [The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-hippocampal System, Oxford University Press, New York, 1982], the hippocampus and the septum act in concert to control anxiety. We found that micro-infusion of midazolam into the dorsal hippocampus increased rats' open-arm exploration in the elevated plus-maze. Co-infusion of L-glutamate into the septum suppressed this anxiolytic effect. However, intra-hippocampal midazolam failed to alter rats' burying behavior in the shock-probe test. These findings suggest that the hippocampus and septum work together to regulate rats' behaviors in some (plus-maze) but not all (burying) animal tests of anxiety.

[Indexed for MEDLINE]

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