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Semin Immunol. 2000 Dec;12(6):551-60.

Diverse CD1d-restricted T cells: diverse phenotypes, and diverse functions.

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Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Smith Building-Room 518, One Jimmy Fund Way, Boston, MA 02115, USA.


Invariant CD1d-restricted T cells express NK cell markers and use a limited TCR repertoire. Here, we describe a second CD1d-restricted T cell subset that uses a diverse TCR repertoire. These T cells can also express NK cell markers and function similarly to invariant T cells. The antigens recognized by the diverse subset are likely to be different from those recognized by invariant TCRs. The variable NK1.1 antigen expression on these T cell populations limits its usefulness in identifying CD1d-restricted T cells. Lastly, the discovery of antigens recognized by diverse CD1d-restricted T cells will provide insight into their role in normal and pathological immune responses.

[Indexed for MEDLINE]

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