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Pediatr Infect Dis J. 2000 Dec;19(12 Suppl):S147-52.

Five-day cefdinir course vs. ten-day cefprozil course for treatment of acute otitis media.

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1
Kentucky Pediatric Research, Bardstown, USA.

Abstract

OBJECTIVE:

To compare the clinical efficacy of a 5-day cefdinir course with a 10-day cefprozil course in the treatment of pediatric acute otitis media (AOM).

DESIGN:

Comparative, investigator-blinded multicenter trial.

SETTING:

Primary care, ambulatory.

PATIENTS:

Children ages 6 months through 12 years with clinical symptoms and tympanic membrane signs of AOM, plus tympanometric-confirmed middle ear effusion in at least 1 ear. Of the 435 patients enrolled in the study, 373 were evaluable.

INTERVENTION:

Patients received cefdinir 14 mg/ kg/day divided twice a day for 5 days or cefprozil 30 mg/kg/day divided twice a day for 10 days.

MAIN OUTCOME MEASURES:

Clinical resolution of tympanic membrane signs and symptoms of AOM determined at end of therapy on Study Days 9 to 11.

RESULTS:

The clinical cure rate at end of therapy was 80% (152 of 190) for cefdinir-treated patients and 82.5% (151 of 183) for cefprozil-treated patients (95% confidence interval, 10.43% to 5.4%). Diarrhea and overall adverse reactions, respectively, occurred in 7.8 and 13% of cefdinir-treated patients and in 4.2 and 12% of cefprozil-treated patients.

CONCLUSIONS:

A short course 5-day regimen of cefdinir was as clinically effective and well-tolerated as a 10-day regimen of cefprozil in the treatment of nonrefractory AOM.

PMID:
11144396
[Indexed for MEDLINE]
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