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Bioorg Med Chem Lett. 2001 Jan 8;11(1):51-4.

Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.

Author information

1
Department of Chemistry, UMIST, Manchester, UK. lawrencenj1@cardiff.ac.uk

Abstract

A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest.

PMID:
11140732
[Indexed for MEDLINE]

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