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Nature. 2000 Dec 21-28;408(6815):982-5.

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

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1
Department of Pharmacology, University of South Florida, Tampa 33612, USA. dmorgan@hsc.usf.edu

Erratum in

  • Nature 2001 Aug 9;412(6847):660.

Abstract

Vaccinations with amyloid-beta peptide (A beta) can dramatically reduce amyloid deposition in a transgenic mouse model of Alzheimer's disease. To determine if the vaccinations had deleterious or beneficial functional consequences, we tested eight months of A beta vaccination in a different transgenic model for Alzheimer's disease in which mice develop learning deficits as amyloid accumulates. Here we show that vaccination with A beta protects transgenic mice from the learning and age-related memory deficits that normally occur in this mouse model for Alzheimer's disease. During testing for potential deleterious effects of the vaccine, all mice performed superbly on the radial-arm water-maze test of working memory. Later, at an age when untreated transgenic mice show memory deficits, the A beta-vaccinated transgenic mice showed cognitive performance superior to that of the control transgenic mice and, ultimately, performed as well as nontransgenic mice. The A beta-vaccinated mice also had a partial reduction in amyloid burden at the end of the study. This therapeutic approach may thus prevent and, possibly, treat Alzheimer's dementia.

PMID:
11140686
DOI:
10.1038/35050116
[Indexed for MEDLINE]
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