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Ital Heart J Suppl. 2000 Sep;1(9):1160-3.

[Nitrates and nitric oxide].

[Article in Italian]

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Laboratorio di Fisiopatologia Cardiovascolare, Fondazione Salvatore Maugeri, IRCCS, Via Pinidolo, 23 25064 Gussago, BS.


Nitrovasodilators are pro-drugs able to release nitric oxide. They have been used in clinical practice for about 100 years and they are still widely used in the treatment of several diseases such as angina pectoris, acute pulmonary edema, and hypertensive crises. This article discusses the pharmacological differences of nitrovasodilators, describes the biochemical pathway of nitric oxide formation, and suggests some criteria to achieve the best therapeutic results.

[Indexed for MEDLINE]

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