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Br J Cancer. 2001 Jan 5;84(1):116-9.

Germline TP53 alterations in Finnish breast cancer families are rare and occur at conserved mutation-prone sites.

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1
Department of Clinical Genetics, University of Oulu/Oulu University Hospital, Oulu, Finland.

Abstract

We have screened for germline TP53 mutations in Finnish BRCA1 and BRCA2 mutation-negative families. This study represents the largest survey of the entire protein-encoding portion of TP53, and indicates that mutations are only found at conserved domains in breast cancer families also meeting the criteria for Li-Fraumeni/Li-Fraumeni-like syndrome, explaining only a very small additional fraction of the hereditary breast cancer cases.

PMID:
11139324
PMCID:
PMC2363618
DOI:
10.1054/bjoc.2000.1530
[Indexed for MEDLINE]
Free PMC Article
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