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J Mol Evol. 2001 Jan;52(1):78-84.

Identification of four families of peptidoglycan lytic transglycosylases.

Author information

1
Department of Microbiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada.

Abstract

The lytic transglycosylases are a class of autolysins which cleave the bacterial cell wall heteropolymer peptidoglycan (murein) to facilitate its biosynthesis and turnover. A search of the National Center for Biotechnology Information (NCBI) databases using the primary sequences of the six characterized lytic transglycosylases of Escherichia coli, a membrane-bound form of the enzyme from Pseudomonas aeruginosa, and the endolysins of lambda bacteriophage permitted the identification of a total of 127 known and hypothetical enzymes from a wide variety of bacteria and bacteriophage. These amino acid sequences have been arranged into four families based on alignments, and consensus motifs have been identified. Family 1 represents a superfamily comprising 86 sequences which are subdivided into five (1A--1E) subfamilies.

PMID:
11139297
DOI:
10.1007/s002390010136
[Indexed for MEDLINE]

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