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Curr Opin Hematol. 2001 Jan;8(1):47-51.

Th1 and Th2 cells.

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Department of Immunology, University of Washington School of Medicine, Seattle, USA.


After activation, CD4 helper T (Th) cells differentiate into Th1or Th2 effector subsets. These two types of cells produce distinct profiles of cytokines and regulate different immune responses. This review summarizes recent progress on different features of co-stimulatory regulation and chemokine-mediated homing of Th1 and Th2 cells. Transcription factors and signaling pathways that are selectively expressed or activated in Th1 and Th2 cells to regulate cytokine gene expression are discussed.

[Indexed for MEDLINE]

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