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J Neuroimmunol. 2001 Feb 1;113(1):146-52.

Lymphocyte populations in Parkinson's disease and in rat models of parkinsonism.

Author information

1
Immunology Service, Hospital Duran i Reynals, CSU de Bellvitge, Autovia de Castelldefels Km 2.7, L'Hospitalet de Llobregat, 08907 Barcelona, Catalonia, Spain. jbas@csub.scs.es

Abstract

To assess the involvement of the immune system in Parkinson's disease we studied the phenotype of circulating lymphocytes in 30 untreated and 34 treated patients. We found a numeric decrease in helper T cells (higher in CD4(+)CD45RA(+) than in CD4(+)CD29(+)) and B cells, and a rise in activated, CD4(+)CD25(+) lymphocytes that was correlated with lymphocyte depletion. All these alterations were independent of levodopa treatment. In addition, we performed striatal dopamine depletion in rats with either MPP(+) or 6-OHDA, showing that MPP(+) but not 6-OHDA can increase CD4(+)CD25(+) lymphocytes. Thus, mechanisms other than dopamine deficit may explain the immune activation in Parkinson's disease.

PMID:
11137586
DOI:
10.1016/s0165-5728(00)00422-7
[Indexed for MEDLINE]

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