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Int J Biochem Cell Biol. 2000 Nov-Dec;32(11-12):1123-36.

Regulation of death receptor-mediated apoptosis pathways.

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Tumorimmunology Program, Division of Immunogenetics, German Cancer Research Centre, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.


Apoptosis or programmed cell death can be induced by a variety of stimuli including activation of death receptors. This subgroup of the TNF/NGF-receptor-superfamily activates caspases, a family of aspartyl-specific cysteine-proteases, which are the main executioners of apoptosis. Depending on the cell type, signalling pathways downstream of the death receptors can be modulated by different proteins such as Bcl-2, FLIPs, chaperones and kinases. Deregulation of apoptosis has been associated with diseases as cancer, autoimmunity and AIDS. Therefore, the identification of modulators of apoptosis has several therapeutic implications.

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