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J Dermatol Sci. 2000 Dec;24 Suppl 1:S46-50.

Regulation of keratinocyte function by growth factors.

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  • 1Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho, Onsen-gun, 791-0295, Ehime, Japan.


Various kinds of growth factors are involved in the regulation of human keratinocyte function. Among them, the epidermal growth factor (EGF) family and the transforming growth factor-beta (TGF-beta) family play central roles, providing dual-mode regulation of keratinocyte growth through the proliferation-stimulating effect of EGF and the proliferation-inhibiting effect of TGF-beta. Human keratinocytes synthesize four EGF family growth factors, TGF-alpha, amphiregulin, HB-EGF and epiregulin, which efficiently regulate keratinocyte growth and differentiation via auto- and cross-induction pathways. Human keratinocytes also synthesize TGF-beta1 and TGF-beta2, which are potent inhibitors of human keratinocytes. These intrinsic EGF family growth factors and TGF-betas are responsible for the autonomous growth regulation of keratinocytes.

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