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Microbes Infect. 2000 Nov;2(14):1743-56.

Hepatitis C virus and interferon resistance.

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Department of Molecular Microbiology and Immunology, University of Southern California, School of Medicine, 2011 Zonal Avenue, Los Angeles, CA 90089, USA.


Interferon plays a critical role in the host's natural defense against viral infections and in their treatment. It is the only therapy for hepatitis C virus (HCV) infection; however, many virus isolates are resistant. Several HCV proteins have been shown to possess properties that enable the virus to evade the interferon-mediated cellular antiviral responses.

[Indexed for MEDLINE]

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