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Microbes Infect. 2000 Nov;2(14):1721-31.

The role of quorum sensing in the in vivo virulence of Pseudomonas aeruginosa.

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Department of Microbiology and Immunology, Texas Tech. University Health Sciences Center, 3601 4th St., Lubbock, Texas, 79430, USA.


Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide variety of infections. The cell-density-dependent signaling mechanisms known as quorum sensing play a role in several of these infections including corneal, lung and burn wound infections. In addition, the quorum-sensing systems contribute to the ability of P. aeruginosa to form biofilms on medically important devices. The quorum-sensing systems accomplish their effect by controlling the production of different virulence factors and by manipulating the host immune response.

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