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Trends Endocrinol Metab. 2001 Jan-Feb;12(1):28-32.

Protein phosphatase 5 in signal transduction.

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Dept of Pharmacology, University of South Alabama, Mobile, AL 36688, USA.


Protein phosphatase 5 (PP5) possesses unique biochemical properties, which include its tetratricopeptide repeat (TPR) targeting/regulatory domain and its ability to be activated by lipids. PP5 has been studied as a paradigm for TPR protein structure and function. Roles for PP5 in signal transduction are emerging: from cell cycle regulation and signaling by nuclear receptors, to possible regulation of membrane receptors and ion channels.

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