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Curr Biol. 2000 Dec 14-28;10(24):R891-5.

Actin dynamics: assembly and disassembly of actin networks.

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  • 1Department of Cell Biology and Physiology, Washington University, Box 8228, 660 S. Euclid Avenue, St. Louis, Missouri 63110, USA.


Assembly of branched actin filament networks at the leading edge of migrating cells requires stimulation of the Arp2/3 complex by WASp proteins, in concert with the WASp activators Cdc42, PIP(2) and profilin. Network disassembly and debranching appears to be linked to actin-bound ATP hydrolysis as filaments age.

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