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J Clin Microbiol. 2001 Jan;39(1):385-8.

Comparison of in vitro activities of voriconazole and five established antifungal agents against different species of dermatophytes using a broth macrodilution method.

Author information

1
Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284-7881, USA. PEREA@UTHSCSA.EDU

Abstract

The in vitro activities of voriconazole against 19 different species of dermatophytes were compared with those of terbinafine, itraconazole, ketoconazole, griseofulvin, and fluconazole. MICs were determined according to a National Committee for Clinical Laboratory Standards broth macrodilution method. Voriconazole appeared more active than ketoconazole, griseofulvin, and fluconazole and less active than itraconazole and terbinafine. Based on these results, voriconazole merits further investigation as a potentially useful agent for the treatment of dermatophytosis.

PMID:
11136808
PMCID:
PMC87739
DOI:
10.1128/JCM.39.1.385-388.2001
[Indexed for MEDLINE]
Free PMC Article

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