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Am J Psychiatry. 2001 Jan;158(1):116-8.

Magnetic resonance imaging of the thalamus in first-episode psychosis.

Author information

1
Section of Cognitive Psychopharmacology, Division of Psychological Medicine, Institute of Psychiatry, University of London, London, UK.

Abstract

OBJECTIVE:

There is some evidence of thalamic abnormalities in schizophrenia. This study investigated thalamic volumes in patients experiencing their first episode of psychosis and nonpsychotic comparison subjects.

METHOD:

Magnetic resonance imaging scans were obtained for 38 patients and 29 comparison subjects. Patients' symptoms were rated by research psychiatrists using the Positive and Negative Syndrome Scale.

RESULTS:

Thalamic volumes were smaller in patients than in comparison subjects. There were no significant correlations between thalamic volumes and symptom scores.

CONCLUSIONS:

Thalamic abnormalities are present close to the onset of psychosis.

PMID:
11136642
DOI:
10.1176/appi.ajp.158.1.116
[Indexed for MEDLINE]

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