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Nat Immunol. 2001 Jan;2(1):23-7.

On guard--activating NK cell receptors.

Author information

1
Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, CA 94143-0414, USA. lanier@itsa.ucsf.edu

Abstract

Although natural killer (NK) cells are known to preferentially kill cells that lack major histocompatibility complex class I antigens, we do not know what signals the attack of these targets. Several membrane receptors have recently been implicated in this process and include molecules with immunoreceptor tyrosine-based activation motifs (ITAM) and motifs that bind phosphoinositide-3 kinase (PI3K). Evidence is emerging that NK cells may use a combination of several receptors and signaling pathways to protect the host against infection and possibly against malignancies.

PMID:
11135574
DOI:
10.1038/83130
[Indexed for MEDLINE]

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