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Bioessays. 2001 Jan;23(1):8-11.

Different ways to make a head.

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Max-Planck-Institut für biophysikalische Chemie, Abteilung für molekulare Entwicklungsbiologie, Am Fassberg 11, D-37077 Göttingen, Germany.


In Drosophila, the establishment of the larval head and thorax depends on the transcription factors BICOID and HUNCHBACK, and on signalling mediated by the receptor tyrosine kinase TORSO. Genetic experiments described in two recent papers(1, 2) demonstrate that these factors can, to a large extent, replace each other, revealing a surprising degree of plasticity in establishing larval anterior structures. The commutability of developmental factors might in part reflect the evolutionary history of the system. BioEssays 23:8-11, 2001.

[Indexed for MEDLINE]

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