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J Virol. 2001 Jan;75(2):1061-4.

Recombinant expression of lymphocytic choriomeningitis virus strain WE glycoproteins: a single amino acid makes the difference.

Author information

1
Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg, D-20251 Hamburg, Germany.

Abstract

Cytoplasmic vector systems are generally used for expression of lymphocytic choriomeningitis virus (LCMV) proteins. However, we achieved high levels of cell surface glycoproteins using a standard nuclear expression plasmid. Expression was independent of other LCMV proteins but was blocked by a missense mutation within the original LCMV(WE) glycoprotein cDNA.

PMID:
11134321
PMCID:
PMC114004
DOI:
10.1128/JVI.75.2.1061-1064.2001
[Indexed for MEDLINE]
Free PMC Article

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