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Bioorg Med Chem Lett. 2000 Dec 18;10(24):2811-3.

Synthesis and biological evaluation of analogues of bacterial lipid I.

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  • 1Department of Chemistry, Incara Research Laboratories, Cranbury, NJ 08536, USA.


Bacterial Lipid I analogues containing different anomeric groups at the muramic acid moiety were synthesized and screened in MurG enzyme assays run in the presence and absence of cell wall membranes. The results obtained in this study help elucidate the role of the lipid diphosphate in the recognition of Lipid I by MurG.

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