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J Hepatol. 2000 Dec;33(6):975-9.

Predictive value of gross classification of hepatocellular carcinoma on recurrence and survival after hepatectomy.

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  • 1Department of Surgery, Graduate School of Medicine, University of Tokyo, Japan.



A new gross classification of hepatocellular carcinoma in which Eggel's nodular type is subclassified into type 1 (single nodular type), type 2 (single nodular type with extranodular growth), and type 3 (contiguous multinodular type) has been widely used in Japan. The aim of the study was to determine whether this classification is correlated with patient outcome.


Sixty-five resected hepatocellular carcinoma nodules (< or = 5 cm) were classified using this new classification.


The 65 tumors were classified into 30 type 1 (46%), 20 type 2 (31%), and 15 type 3 (23%) hepatocellular carcinomas. The rate of microscopic vascular invasion significantly increased from type 1 to type 2, and to type 3 tumors (p=0.03). Kaplan-Meier estimates showed that type 1 was significantly associated with lower recurrence rate (type 1 vs. type 2, p=0.01; type 1 vs. type 3, p=0.004; log-rank test), and higher disease-specific survival (type 1 vs. type 2, p=0.02; type 1 vs. type 3, p=0.002). Cox's proportional-hazards model demonstrated that type 1 was an independent factor for low risk of recurrence (p=0.002) and low risk of disease-specific death (p=0.02).


The gross classification of hepatocellular carcinoma is of clinical value in predicting patient outcome.

[PubMed - indexed for MEDLINE]
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