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J Neuroophthalmol. 2000 Dec;20(4):227-8.

Acute effects of sildenafil (viagra) on blue-on-yellow and white-on-white Humphrey perimetry.

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1
Bascom Palmer Eye Institute, University of Miami, Florida, USA.

Abstract

OBJECTIVE:

To study the effects of sildenafil on blue-on-yellow and white-on-white Humphrey visual field (HVF).

MATERIALS AND METHODS:

Healthy subjects, ages 20 to 38 years, were prospectively randomized to active drug (n = 5) or placebo (n = 3) groups. Blue-on-yellow and white-on-white HVF testing was performed before and 1 hour after masked dosing of sildenafil 200 mg or placebo. Changes in mean deviation (MD) were compared between groups.

RESULTS:

Three of three placebo and four of five sildenafil subjects had no change on HVF. One of five sildenafil subjects had a decrease in MD of 17.9 dB and 4.7 dB on blue-on-yellow and white-on-white HVF testing, respectively. This subject reported more systemic side effects than other subjects.

CONCLUSIONS:

Sildenafil has no effect on HVF testing in most persons; however, sildenafil caused an acute abnormality of HVF testing in one subject, who experienced pronounced non-visual systemic symptoms; this effect was greater on blue-on-yellow than white-on-white HVF.

PMID:
11130743
[Indexed for MEDLINE]
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