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Amino Acids. 2000;19(2):477-82.

Resolution of DL-hydantoins by D-hydantoinase from Vigna angularis: production of highly enantioenriched N-carbamoyl-D-phenylglycine at 100% conversion.

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  • 1Instituto de QuĂ­mica, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, RJ, Brasil.

Abstract

D-Hydantoinase from Vigna angularis hydrolyzed rac-5-monosubstituted-hydantoins with polar and aromatic side chains and dihydrothymine but rac-5,5-disubstituted-hydantoins were not substrates of this enzyme. 5-Phenylhydantoin was the best substrate. By using this substrate, Ncarbamoyl-D-phenylglycine was obtained in quantitative yield and over 98% ee.

PMID:
11128554
[PubMed - indexed for MEDLINE]
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