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Int J Obes Relat Metab Disord. 2000 Nov;24 Suppl 4:S8-10.

Regulation of adipogenesis and energy balance by PPARgamma and PGC-1.

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Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA.


There has been a great deal of recent progress in our understanding of the transcriptional control of adipogenesis. Current data suggest that fat cell differentiation involves an interplay between the C/EBP family of transcription factors and PPARgamma. The thermogenic program of brown fat cells may also include a contribution from a new coactivator, PGC-1. Recent data suggests that this coactivator is responsible for activation of thermogenesis and oxidative metabolism in both brown fat and muscle. The PGC-1 dependent program includes both mitochondrial biogenesis and tissue-specific expression of uncoupling proteins.

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