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J Urol. 2001 Jan;165(1):153-8.

Periurethral autologous fat injection as treatment for female stress urinary incontinence: a randomized double-blind controlled trial.

Author information

1
Department of Obstetrics and Gynecology, University of Toronto, Sunnybrook and Women's College Health Sciences Centre and Mount Sinai Hospital, Toronto, Ontario, Canada.

Abstract

PURPOSE:

We evaluated the effectiveness of periurethral autologous fat injection as treatment for female stress urinary incontinence.

MATERIALS AND METHODS:

Women with stress incontinence were randomized in a double-blind fashion to receive periurethral injections of autologous fat (treatment group) or saline (placebo group). After injection patients were evaluated monthly for 3 months by a validated standardized incontinence questionnaire, 1-hour pad test and cough test. Patients who remained incontinent were offered repeat injection using the same initial agent to a maximum of 3 injections. Every 3 months after injection patients were assessed by a standardized questionnaire, pad test, cough test and urodynamics. Those who did not qualify for repeat injection at 3 months were then followed 6, 9, 12, 18 and 24 months or until failure.

RESULTS:

Of the 68 women enrolled 35 received fat and 33 received saline injections. The groups were comparable in terms of baseline parameters. A total of 56 patients completed the study, including 27 in the fat and 29 in the placebo group, for a total of 189 injections (91 fat and 98 saline). At 3 months 6 of 27 (22.2%) and 6 of 29 (20.7%) women were cured or improved in the fat and saline groups, respectively. Complications included cystitis in 9 of 189 injections, urinary retention in 6 in the fat injection group, urge incontinence in 9 of 68 patients and pulmonary fat embolism resulting in death in 1 of 189 procedures.

CONCLUSIONS:

In this study periurethral fat injection did not appear to be more efficacious than placebo for treating stress incontinence.

[Indexed for MEDLINE]

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