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Clin Lab Haematol. 2000 Oct;22(5):307-8.

T cell lymphocytosis associated with polymyositis, myasthenia gravis and thymoma.

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Department of Haematology, Bristol Royal Infirmary, Bristol, UK.


Peripheral T cell lymphocytosis is a rare finding in association with malignant thymomas. In the majority of previous cases, the tumours have behaved aggressively with symptoms arising from local invasion. We describe a patient with ocular myasthenia gravis who presented with a rapidly progressive polymyositis and neuropathy and who was subsequently found to have a thymic mass and a mild T cell lymphocytosis. The thymoma did not give rise to local symptoms and showed no evidence of progression over a 14-month period of follow-up. The possibility of an underlying thymic tumour should be considered in any patient with chronic T cell lymphocytosis if the circulating cells show mature morphology and there is no molecular evidence of monoclonality.

[Indexed for MEDLINE]

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