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Parasitol Today. 2000 Dec;16(12):536-40.

Molecular crosstalk in host-parasite relationships: schistosome- and leech-host interactions.

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Laboratoire d'Endocrinologie des Annélides, UPRES-A CNRS 8017, SN3, Université des Sciences et Technologies de Lille, 59655 Villeneuve d'Ascq, Cédex, France.


The host-parasite relationship is based on subtle interplay between parasite survival strategies and host defense mechanisms. In this context, parasites often use the same or similar immune signaling molecules and/or molecular mimicry to escape host immunosurveillance. Both processes represent an adaptive strategy to ensure host immunocompatibility. This bidirectional communication between parasites and their hosts includes the renin-angiotensin, opioid and opiate systems. Here, Michel Salzet, André Capron and George Stefano review recent work on the interaction of common signaling mechanisms in schistosomes, leeches and their host.

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[Indexed for MEDLINE]

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