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Biochim Biophys Acta. 2000 Dec 1;1494(3):286-9.

Cloning and functional expression of the rat alpha(2) subunit of soluble guanylyl cyclase.

Author information

1
Institut für Experimentelle und Klinische Pharmakologie, Universität Hamburg, Martinistrasse 52, D-20251 Hamburg, Germany.

Abstract

Nitric oxide-sensitive guanylyl cyclase is a heterodimeric enzyme consisting of one alpha and one beta subunit. Here, we clone the first alpha(2) subunit ortholog and functionally express the cDNA in Sf-9 cells. Our data indicate a high degree of conservation of the primary sequence and functional activity of the rat alpha(2) subunit.

PMID:
11121588
DOI:
10.1016/s0167-4781(00)00211-6
[Indexed for MEDLINE]

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