Format

Send to

Choose Destination
J Infect Dis. 2001 Jan 15;183(2):232-238. Epub 2000 Dec 13.

Effect of azithromycin on murine arteriosclerosis exacerbated by Chlamydia pneumoniae.

Author information

1
Division of Cardiology, Dept. of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Chlamydia pneumoniae infection can exacerbate atherosclerosis in animals. To test the hypothesis that antibiotic therapy inhibits the atherogenic effects of C. pneumoniae infection, 10-week-old apolipoprotein E (ApoE) null mice were infected with C. pneumoniae or placebo, were treated for 2 weeks after infection with azithromycin or placebo, and were killed at 20 weeks of age. Infection did not affect the size of the aortic lesion, and antibiotic treatment had no effect. Another group of mice, 12-week-old ApoE mice, were infected with C. pneumoniae or placebo, were treated for 2 weeks after infection with azithromycin or placebo, and were killed at 26 weeks of age. C. pneumoniae infection increased the size of the lesion in infected mice, but azithromycin did not reduce the size of the aortic lesion in infected mice. Therefore, immediate therapy of acute infection may be necessary to prevent the proatherogenic effects of C. pneumoniae infection.

PMID:
11120929
DOI:
10.1086/317941
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center