Format

Send to

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 2000 Dec 15;486(3):315-9.

The human PER1 gene is transcriptionally regulated by multiple signaling pathways.

Author information

1
IPF PharmaCeuticals GmbH, Hannover, Germany.

Abstract

The mammalian period (Per) genes are components of the circadian clock and appear to be regulated via an autoregulatory feedback loop. Here we show that the human PER1 (hPER1) gene is synergistically activated by protein kinases A and C (PKA, PKC) and cAMP responsive element binding protein. Activators and inhibitors of PKA as well as PKC modulate endogenous hPER1 expression and hPER1 promoter-driven reporter gene activity in a dose-dependent manner. Our results suggest that the hPER1 promoter acts as a sensor for multiple signaling molecules thereby integrating different physiological parameters. This regulation of hPER1 appears to be significant for rapid adaptation to changing environmental conditions.

PMID:
11119726
[Indexed for MEDLINE]
Free full text

Publication type, MeSH terms, Substances

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center