Format

Send to

Choose Destination
FEBS Lett. 2000 Dec 15;486(3):281-4.

CREB is cleaved by caspases during neural cell apoptosis.

Author information

1
Institute of Molecular Biosciences, Massey University, Private Bag 11222, Palmerston North, New Zealand.

Abstract

Programmed cell death, or apoptosis, is a tightly regulated process mediated by selective cleavage of proteins by caspases, resulting in ordered destruction of the cell. In addition to structural proteins, proteins that mediate anti-apoptotic signal transduction are also substrates; their destruction eliminates potential futile attempts to escape execution. We asked whether cAMP response element binding protein (CREB), a transcription factor that mediates nerve growth factor (NGF) survival signals, is a target for caspases during apoptosis. CREB was specifically cleaved by caspases in neuroblastoma extracts, and in cells induced to undergo apoptosis by staurosporine. The destruction of CREB eliminates a key factor that could reverse apoptosis.

PMID:
11119719
DOI:
10.1016/s0014-5793(00)02316-4
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center