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FEBS Lett. 2000 Dec 15;486(3):267-9.

Consensus predictions of membrane protein topology.

Author information

1
Stockholm Bioinformatics Center, Department of Biochemistry, Stockholm University, Sweden.

Abstract

We have explored the possibility that consensus predictions of membrane protein topology might provide a means to estimate the reliability of a predicted topology. Using five current topology prediction methods and a test set of 60 Escherichia coli inner membrane proteins with experimentally determined topologies, we find that prediction performance varies strongly with the number of methods that agree, and that the topology of nearly half of all E. coli inner membrane proteins can be predicted with high reliability (>90% correct predictions) by a simple majority-vote approach.

PMID:
11119716
DOI:
10.1016/s0014-5793(00)02321-8
[Indexed for MEDLINE]
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