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Mech Dev. 2001 Jan;100(1):65-9.

A reporter transgene based on a human keratin 6 gene promoter is specifically expressed in the periderm of mouse embryos.

Author information

1
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 725 N. Wolfe St., Baltimore, MD 21205, USA.

Abstract

We report the developmental regulation of a lacZ reporter transgene fused to the promoter region of the human keratin 6a gene. In mouse embryos, the transgene is expressed in the periderm (the outermost layer of embryonic epidermis), as are the endogenous keratin 6 alpha and beta genes. A subset of periderm cells, localized to temporary epithelial fusions, is known to contain keratin 6 protein, and we find that these cells also harbor LacZ enzymatic activity.

PMID:
11118885
DOI:
10.1016/s0925-4773(00)00489-5
[Indexed for MEDLINE]
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