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Vet Microbiol. 2000 Dec 20;77(3-4):465-73.

Transitions in immune responses to Mycobacterium paratuberculosis.

Author information

1
USDA-ARS, National Animal Disease Center, Ames, IA 50010, USA. jstabel@nadc.ars.usda.gov

Abstract

The host immune response to infection with Mycobacterium paratuberculosis is paradoxical, with strong cell-mediated immune responses during the early, subclinical stages of infection and strong humoral responses during the late clinical stages of the disease. Cell-mediated immune responses modulated by various T cell subsets are essential to provide protective immunity and prevent progression of the disease. Secretion of cytokines by T cell populations serves to activate macrophages to kill ingested M. paratuberculosis as well as activate other T cell subsets to contain the infection. This paper reviews the current knowledge of T cell immune responses in M. paratuberculosis infection based upon clinical studies and research using mouse models.

PMID:
11118731
[Indexed for MEDLINE]

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