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Clin Infect Dis. 2001 Jan;32(1):144-8. Epub 2000 Dec 13.

Reactivation of hepatitis B virus replication accompanied by acute hepatitis in patients receiving highly active antiretroviral therapy.

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1
Klinische Abteilung, Bernhard-Nocht-Institut für Tropenmedizin, Hamburg, Germany. manegold@bni.uni-hamburg.de

Abstract

We describe 2 patients who were initially positive for antibodies to hepatitis B surface antigen and who experienced a strong and sudden increase of hepatitis B virus (HBV) replication during highly active antiretroviral therapy (HAART). We found that reactivation of HBV replication during HAART can occur independently of lamivudine resistance or withdrawal of lamivudine, and in spite of increasing CD4(+) cell counts.

PMID:
11118394
DOI:
10.1086/317535
[Indexed for MEDLINE]
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