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Biochem Biophys Res Commun. 2000 Dec 20;279(2):574-81.

Expression and evolution of the Drosophila attacin/diptericin gene family.

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Umeâ Centre for Molecular Pathogenesis, Umeâ University, Umeâ, S-901 87, Sweden.

Erratum in

  • Biochem Biophys Res Commun 2001 Feb 9;280(5):1415.


We describe the genes for three new glycine-rich antimicrobial peptides in Drosophila, two attacins (AttC and AttD) and one diptericin (DptB). Their structures support the proposal that these glycine-rich antimicrobial peptides evolved from a common ancestor and are probably also related to proline-rich peptides such as drosocin. AttC is similar to the nearby AttA and AttB genes. AttD is more divergent and located on a different chromosome. Intriguingly, AttD may encode an intracellular attacin. DptB is linked in tandem to the closely related Diptericin. However, the DptB gene product contains a furin-like cleavage site and may be processed in an attacin-like fashion. All attacin and diptericin genes are induced after bacterial challenge. This induction is reduced in imd mutants, and unexpectedly also in Tl(-) mutants. The 18w mutation particularly affects the induction of AttC, which may be a useful marker for 18w signaling.

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