Format

Send to

Choose Destination
Lancet. 2000 Nov 25;356(9244):1820-1.

Hereditary catalase deficiencies and increased risk of diabetes.

Abstract

Partial or near-total lack of erythrocyte catalase activity is a rare condition, generally thought to be benign. However, little is known of the frequency of common diseases of adult onset in human beings with catalase deficiency. We report that, in a series of Hungarian patients with catalase deficiency, there is a higher frequency of diabetes than in unaffected first-degree relatives and the general Hungarian population. We speculate that quantitative deficiency of catalase might predispose to cumulative oxidant damage of pancreatic beta-cells and diabetes.

PMID:
11117918
DOI:
10.1016/S0140-6736(00)03238-4
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center