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Br J Psychiatry. 2000 Oct;177:336-42.

Association of depression and gender with mortality in old age. Results from the Amsterdam Study of the Elderly (AMSTEL).

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1
Department of Psychiatry, Vrije Universiteit Amsterdam, Valeriusplein 9, 1075 BG Amsterdam, The Netherlands. RA.Schoevers.emgo@med.vu.nl

Abstract

BACKGROUND:

The association between depression and increased mortality risk in older persons may depend on the severity of the depressive disorder and gender.

AIMS:

To investigate the association between major and mild depressive syndromes and excess mortality in community-living elderly men and women.

METHOD:

Depression (Geriatric Mental State AGECAT) was assessed in 4051 older persons, with a 6-year follow-up of community death registers. The mortality risk of neurotic and psychotic depression was calculated after adjustment for demographic variables, physical illness, cognitive decline and functional disabilities.

RESULTS:

A total of 75% of men and 41% of women with psychotic depression had diet at follow-up. Psychotic depression was associated with significant excess mortality in both men and women. Neurotic depression was associated with a 1.67-fold higher mortality risk in men only.

CONCLUSIONS:

In the elderly, major depressive syndromes increase the risk of death in both men and women, but mild depression increases the risk of death only in men.

PMID:
11116775
[Indexed for MEDLINE]
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