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Trends Biochem Sci. 2000 Dec;25(12):596-601.

The regulation of protein function by multisite phosphorylation--a 25 year update.

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MRC Protein Phosphorylation Unit, MSI/WTB Complex, University of Dundee, Dundee, UK DD1 5EH.


The phosphorylation of a protein can alter its behaviour in almost every conceivable way. These include modulation of its intrinsic biological activity, subcellular location, half-life and docking with other proteins. 'Multisite phosphorylation can enable several such effects to operate in the same protein. It can also determine the extent and duration of a response and is the key to signal integration.

[Indexed for MEDLINE]

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