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Trends Microbiol. 2000 Dec;8(12):565-70.

Why Helicobacter pylori has Lewis antigens.

Author information

1
Dept of Medical Microbiology, Vrije Universiteit, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands. bj.appelmelk.mm@med.vu.nl

Abstract

In mimicry with human gastric epithelial cells, the lipopolysaccharide of Helicobacter pylori expresses Lewis blood group antigens. Recent data suggest that molecular mimicry does not promote immune evasion, nor does it lead to induction of autoantibodies, but that H. pylori Lewis X mediates adhesion to gastric epithelial cells and is essential for colonization.

PMID:
11115753
DOI:
10.1016/s0966-842x(00)01875-8
[Indexed for MEDLINE]

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